American Board of Orthodontics (ABO) Practice Exam

Opioids are known to have a direct impact on the central nervous system, and one of their effects includes the modulation of blood pressure. When opioids are administered, they can lead to vasodilation, which is the widening of blood vessels. This vasodilation can result in a decrease in systemic vascular resistance, consequently lowering blood pressure.

Additionally, opioids can cause a decrease in heart rate and respiratory depression, which also contribute to a drop in blood pressure. The overall cardiovascular effect of opioids, particularly at higher doses or in sensitive populations, tends to lean towards lowering blood pressure. Consequently, this understanding affirms that opioids generally decrease blood pressure, which aligns with the answer provided.

It's important to note that while individuals might react differently based on numerous factors such as age, overall health, and concurrent use of other medications, the fundamental pharmacologic action of opioids leads to a decrease in blood pressure in most cases.